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KMID : 0882420070720040368
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Korean Journal of Medicine
2007 Volume.72 No. 4 p.368 ~ p.375
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Immunohistochemical comparison of the telomerase expression between low-grade and high-grade gastric dysplasia.
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Oh Young-Sang
Kim Ho-Dong
Moon Seung-Won
Jeong Jong-Hyeok
Kim Dong-Han
Yang Hyuk-Seung
Kim Soo-Hyun
Kim Sang-Pil
Jeon Won-Jeong
Park Hyuk
Choi Jeong-Young
Kim Do-Hyeon
Lee Young-Jik
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Abstract
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Background: Telomeres are simple repeats elements located at each end of the chromosomes of eukaryotic cells. The main function of telomeres is to cap the chromosome end and protect it from enzymatic attack. Telomerase that facilitates the synthesis of telomere has been detected in not only cancer, but also in precancerous lesion. In this study, we compared the telomerase expression between low-grade and high-grade gastric dysplasia.
Methods: The telomerase expression of 43 patients with gastric dysplasia (22 low-grade and 21 high-grade) was evaluated by immunohistochemical staining in tissues.
Results: The telomerase expression was much higher in the tissues from the patients with high-grade gastric dysplasia than in those tissues of the patients with low-grade gastric dysplasia.
Conclusion: Activation of telomerase may be related with the malignant potentiality in gastric cells. Further studies are needed to define the role of telomerase in gastric tumorigenesis.
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KEYWORD
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Dysplasia, Telomerase, Immunohistochemistry
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